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DTSTART;TZID=America/Los_Angeles:20211021T033000
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DTSTAMP:20260427T181726
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SUMMARY:Rheological Characterization of Respiratory Secretions in Severe SARS-CoV-2 (COVID-19) Infections
DESCRIPTION:Prof. Andrew J. Spakowitz\, Depts. of Chemical Engineering and Materials Science & Engineering\, Stanford University\nSponsored by the Golden Gate Polymer Forum\nOctober 21st\, 6:30-7:30 pm\, Online via Zoom\, $5 donation/Free\, Registration required (registration deadline Oct. 19th @ 1pm)\n\nAbstract: Thick\, viscous respiratory secretions are common in severe cases of COVID-19 disease and greatly contribute to breathing difficulty. Understanding the polymeric composition and the rheological properties of these secretions can inform the development of treatments to improve the respiratory function of these patients. After measuring the composition of respiratory secretions collected from intubated COVID-19 patients and controls\, we found that DNA content and hyaluronan content were greatly elevated in COVID-19 sputum. Across all patients\, COVID-19 sputum exhibited a wide distribution in rheological properties\, which were measured using dynamic light scattering microrheology. Respiratory secretions from COVID-19 patients had a statistically significant increase in storage moduli compared to healthy controls. We explored the possibility of reducing sputum viscosity by treating the aspirates enzymatically with hyaluronidase or DNase\, which degrade hyaluronan and DNA\, respectively. Interestingly\, there was a strong positive correlation between the shear modulus of COVID-19 sputum and the effect of these enzymes. These results suggest that DNA and hyaluronan may be viable therapeutic targets in COVID-19 infection and could be targeted with FDA-approved enzymes already clinically used for other indications. \nBio: Prof. Spakowitz received his Ph.D. from CalTech\, and is a Professor in both departments of Chemical Engineering and Materials Science & Engineering at Stanford University. The Spakowitz research group is engaged in projects that address fundamental chemical and physical phenomena underlying a range of biological processes and soft-material applications. Current research in his research group focuses on four main research themes: chromosomal organization and dynamics\, protein self-assembly\, polymer membranes\, and charge transport in conducting polymers. These broad research areas offer complementary perspectives on chemical and physical processes\, and they leverage this complementarity throughout their research. This approach draws from a diverse range of theoretical and computational methods\, including analytical theory of semiflexible polymers\, polymer field theory\, continuum elastic mechanics\, Brownian dynamics simulation\, equilibrium and dynamic Monte Carlo simulations\, and analytical theory and numerical simulations of reaction-diffusion phenomena. A common thread in the work is the need to capture phenomena over many length and time scales\, and flexibility in research methodologies provides them with the critical tools to address these complex multidisciplinary problems. \nhttp://web.stanford.edu/~ajspakow/ \n 
URL:https://www.siliconvalleyacs.org/event/rheological-characterization-of-respiratory-secretions-in-severe-sars-cov-2-covid-19-infections/
LOCATION:Virtual
CATEGORIES:Dinner Meeting
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DTSTART;TZID=America/Los_Angeles:20211025T163000
DTEND;TZID=America/Los_Angeles:20211029T023000
DTSTAMP:20260427T181726
CREATED:20210909T132808Z
LAST-MODIFIED:20210909T132808Z
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SUMMARY:Adhesion Science: Principles and Practice (3-Day Live Virtual Short Course)
DESCRIPTION:Professor Timothy Long\, Arizona State University; Professor David A. Dillard\, Virginia Tech; Professor Mike Bortner\, Virginia Tech; Dr. Giles Dillingham\, BTG Labs\nDates: October 26\, 27 and 29\, 2021 (Tuesday\, Wednesday\, and Friday)\nSponsored by the Golden Gate Polymer Forum\nRegistration $500 (until October 4 at 5pm Pacific time).  Learn more and register\n\nCourse Overview\n\nThis 3-day virtual course will address the fundamentals and applications of adhesion science to solve practical adhesive design and bonding challenges. The course will be taught by a well-coordinated team of highly experienced instructors\, and will focus on four fundamental perspectives: adhesive structure-property relationships (Long)\, surface functionalization and characterization (Dillingham)\, polymer rheology and processing (Bortner)\, and design and mechanics of adhesive bonds (Dillard). The course will allow participants to gain a broad perspective of the rapidly evolving field of adhesion science and engineering for emerging technologies from electronics to biomedical sciences. \nAll topics will be presented with an application/use-inspired approach to foster learning\, including by those with limited directly relevant technical education or experience. Attendees can expect to learn about surfaces and interfaces\, polymer structure-property relationships relevant to adhesives\, and the stresses and failure of adhesive joints. Building on these fundamental insights\, participants will gain many practical insights into surface preparation\, time-dependent adhesive characterization\, test method selection\, surface and failure analysis\, joint design\, and adhesive durability. (See detailed topics list in course outline below.) \nThis course offers an exceptional opportunity with a unique combination of four very experienced researchers/teachers from renowned polymer and adhesion science research programs across the nation\, a virtual format to allow broad participation\, an affordable price\, and a focus on practical applications. Q&A sessions will be incorporated throughout each day. \nWho should attend:\n\nAny scientist\, engineer or technician who works with bonding\, joining\, or adhesion issues\, including those using polymeric adhesives or sealants\, and their use in a research\, development\, product design\, manufacturing\, quality control\, or reliability context.\nManagers in polymer and manufacturing industries will greatly benefit from this broad-based introduction to adhesion issues and opportunities in the field.\nThe course is structured for those with some scientific or engineering background and those with industrial experience in technology who would like to learn the basics and fundamentals of adhesion science and applications to practical adhesive bonding and engineering challenges.\n\n\nInstructor Background\nDr. Timothy Long holds a joint faculty position in the School of Molecular Sciences and the School for Engineering\, Matter\, Transport and Energy at Arizona State University. Prof. Long leads the Biodesign Center for Sustainable Macromolecular Materials and Manufacturing within the Biodesign Institute at ASU. His interdisciplinary research group tackles diverse research areas related to the structure-property-processing relationships of polymers with emphasis on sustainable chemistry and engineering\, discovery of novel synthetic methods\, advanced physical characterization tools\, and designing materials with proper reactivity and rheology for additive manufacturing processes. His research has led to over 50 patents and 350 peer-reviewed publications in diverse areas of macromolecular science and engineering. His distinctions include Virginia 2019 Outstanding Faculty Award\, American Chemical Society (ACS) PMSE Cooperative Research Award\, ACS Division of Polymer ChemistryPOLY Mark Scholar Award\, and ACS Fellow (2009). \nDr. David A. Dillard is the Adhesive and Sealant Science Professor in the Biomedical Engineering Science and Mechanics Department at Virginia Tech. He has worked extensively in the field of adhesive bonding\, having experience in structural adhesives for aerospace\, automotive\, and infrastructure applications; adhesives and coatings for microelectronic applications; pressure sensitive adhesives; elastomeric adhesives and sealants\, and polymeric membranes\, sealants and adhesion issues in alternative energy systems. He has coauthored over 200 publications in refereed journals and regularly teaches courses in adhesion science and viscoelasticity. His research activities focus on developing test methods and predictive models for understanding and estimating the performance and durability of adhesives and bonded joints\, using the principles of fracture mechanics and viscoelasticity. He is a Robert L. Patrick Fellow and former President of the Adhesion Society \nDr. Michael J. Bortner is an Associate Professor of Chemical Engineering who specializes in structure-process-property relationships of polymer composite and nanocomposite materials for applications including smart materials and electronics\, structural composites\, next generation extrusion based additive manufacturing materials\, and packaging materials. He implements advanced processing and characterization techniques coupled with numerical modeling to fundamentally understand the interrelationships between intrinsic chemistry-controlled properties\, processing technique\, and resulting morphology/structure-property relationships. He has over 50 peer reviewed journal manuscripts and conference papers and proceedings\, and was recently elected Treasurer of the American Chemical Society Cellulose and Renewable Materials (ACS CELL) Division. He has served as the Chair of the Structural Division of the Adhesion Society and is currently co-chair of the Adhesion Society Annual Meeting. \nDr. Giles Dillingham has worked in the areas of materials\, surfaces\, interfaces\, and adhesive bonding since receiving his Ph.D. in Materials Science in 1987. BTG Labs\, established by Dr. Dillingham in the late 1990’s\, performs basic and applied research in surface science\, surface treatments\, and adhesion\, and also develops and manufactures instrumentation for the control of surface engineering processes. Recent work by BTG Labs is helping pave the way to certifiable adhesively bonded primary aircraft structures. Dr. Dillingham has over 40 publications and patents in the areas of surface treatments\, surface energetics\, and adhesion. He is proud to have been elected a Robert A. Patrick Fellow of The Adhesion Society.
URL:https://www.siliconvalleyacs.org/event/adhesion-science-principles-and-practice-3-day-live-virtual-short-course/
LOCATION:Virtual
CATEGORIES:Short Course
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